God Medicine features standard RPG elements. The three characters can level up through battle and equip weapons and armor. Spells can be learned, as well as Maphu attacks. After the party collects Maphu gems and gains the special Maphu weapons, they can put the gems in the weapons. Each gem has a different effect depending on what character equips it. Some Maphu attacks need to be charged during battle first. The charges last even if the battle is finished. The player can save anytime, except in battle.