Glory of Heracles III's gameplay borrows various motifs from ancient mythology, particularly the concept of immortality. An immortal character can execute certain actions that other characters cannot, like jumping off high cliffs without being injured. The game's writer, Kazushige Nojima, composed a storyline where the hero encounters the Greek gods while trying to discover his own true identity. Like the game's predecessor, Heracles no Eikō II: Titan no Metsubō, the game focuses on its rich storyline rather than the game system, which does not differ significantly from other role-playing video games of the period.